This is just an opinion: For self defense, an extreme tissue cavitation projectile makes sense. For eatin' meat, I'm not so sure. I do know that the 245gr, Brass,
Xtreme Penetrators hold my personal record for the most accurate projectiles that I've ever shot from a 450b. If I were just a near-side shoulder buster, I'd go with the Xtreme Penetrators. Less cavitation than the Xtreme Defense version, which I have not tested for accuracy. My gut feeling is that either will get the job done quite well.
Of course, the old adage that
"you go to war with the army that you have" applies more now than ever, in terms of reloading supplies.
Hoot